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- Annihilator: an advanced android dedicated to
restoring the Manhunter cult
- Abyss: former hero brought back from the dead as a
soldier of evil
- Ace of Thieves
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- Black Wolf
- Blackmane
- Bughouse
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- Enforcer: a shape-changing villain with the ability to
duplicate the powers of anyone he encounters
- Enforcers of Injustice: villain team assembled
by Death Spider for his various revenge plots
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- Fearsome Five: a version of the criminal team led by the
elusive Paradox
- Fearsome Five, New
- Femmes Fatales: an all-women super-criminal team
- Forces of Nature
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- Grandmaster: a master manipulator and gamesman, and one
of the sole surviving clones of Paul Kirk (Manhunter)
- Graveyard Shift: team of horror-themed villains assembled by the Gentleman Ghost
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- Masters of Speed
- Masters of the Elements
- Minions of Set
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- Omega: an Artificial Intelligence dedicated to saving humankind
from itself
- Overlord: the despotic ruler of an extra-dimensional realm who has
twice tried to invade Earth
- Overlord's Elite: Overlord's most powerful underlings
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- P.S.I.
- Predator
- Prophet: the harbinger of Darkness
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- Sharpshooters
- Silver Path: techno-voodoo cult
- Slaughterhouse Seven
- Soldiers of Anarchy: villains dedicated to the spread of chaos,
or so they would have you believe...
- Spinnerette
- Swordsmen
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- Warmonger
- Wilde Family
- World Crime League
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